I find Netscan comes in handy if your firefighting known infections. just scan for a know rogue remote file, or in the case of Conficker c:\windows\tasks\At1.job
You can also use pskill with commandline added to netscan to kill those rogue process'
Also scan for know rogue regkeys. But as Andrew states, Antivirus should be the first line of defense, with a central logging system