I tried RAM File System briefly in my environment. The UI and general operation felt familiar coming from RAM Disk, and it seemed suitable for temporary-use workloads such as OS TEMP, archive extraction, browser cache, and other short-lived files. In light testing, I did not encounter any obvious issues with applications such as Acrobat, Office, archive extraction tools, or browser cache usage.
That said, my main RAM drive use case depends heavily on Everything indexing. Since I use Everything extensively in my daily workflow, having an NTFS volume is important to me. For that reason, I expect to continue using RAM Disk as my main RAM drive.
Still, I find the design and performance direction of RAM File System very interesting. It seems like a promising product for workloads where NTFS compatibility and indexing are not required. I will keep an eye on future updates and may use it for dedicated TEMP-style workloads.