Just installed NetWorx v25.12 on my Win10 system and will not start automatically. I have to start manually by clicking 'C:\Program Files\NetWorx\networx.exe'.
'Start automatically' is ticked in my settings.
Is networx.exe listed in Startup Apps, in Task Manager? If not, uncheck the Start automatically, then hit Apply. Now check Start automatically, then hit Apply. Check if networx.exe is now listed in Startup Apps, in Task Manager.
If that doesn't work, check that other apps (security, anti-virus, system managers) aren't blocking it from starting.